Cao H, Wang Y, Zhong Y, Liu X, Miao M, Duan W, Liu K
[YPK1 overexpression resulted salt stress hypersensitivity in Saccharomyces cerevisiae is dependent on TOR1] [English Abstract, Journal Article, Research Support, Non-U.S. Gov't]
Wei Sheng Wu Xue Bao 2009 Aug 4; 49(8):1069-74.
Serine/threonine protein kinase YPK1, a homologue of mammalian protein kinase serum and glucocorticoid-inducible kinase (SGK), plays important physiological roles in Saccharomyces cerevisiae. It involves in cell wall maintenance, actin cytoskeleton dynamics, endocytosis, translation during nitrogen starvation and nutrient sensing.
OBJECTIVE: In order to further explore the cellular function of YPK1 and the its transduction pathway.
METHODS: We overexpressed YPK1 in wild type and tor1 mutant cells and monitored the cell growth responding to salt stress.
RESULTS: We found that YPK1 overexpression resulted salt stress hypersensitivity in wild type cells and this hypersensitivity was abolished by tor1 mutant.
CONCLUSION: Our results indicate that YPK1 may interact with target of rapamycin (TOR1) to regulate the salt stress response.
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